Bonetta Series · Nasolabial folds, lip augmentation, facial contouring Bonetta Deep — HENM Cross-Linked HA for Nasolabial Folds & Lip Volume (2 × 1.1mL) Bonetta Deep is ExoCoBio’s mid-density workhorse — 24 mg/mL cross-linked hyaluronic acid 0.3% lidocaine using patented HENM cross-linking technology. Supplied as 2 × 1.1 mL pre-filled syringes per box. Engineered for nasolabial folds, lip augmentation, and moderate facial contouring with 9–18 month durability. KFDA registered. Professional use only — for licensed aesthetic practitioners. Manufacturer: ExoCoBio Inc., South Korea · Established 2017 HENM Cross-Linking Tech 2 × 1.1mL Per Box May 2026 Last Reviewed · Verified ExoCoBio Inc. Technology How Bonetta Deep Cross-Linked HA Filler Is Engineered 1 HENM Patented Cross-Linking ExoCoBio Inc.’s proprietary cross-linking process produces a stabilised HA gel matrix engineered for sustained tissue retention. The technology balances viscoelasticity (firmness for projection) with extrusion smoothness (easier injection through the 27G needle). The result: predictable handling, consistent gel distribution, and 9–18 months durability in mid to deep dermis placement. 2 Quality & Purity Non-animal hyaluronic acid produced by bacterial fermentation. Endotoxin levels controlled below international safety thresholds. Stringent manufacturing under GMP-certified conditions minimises BDDE residue, heavy metals, and protein contaminants — reducing the risk of post-injection inflammation, granuloma formation, or hypersensitivity reactions in suitable patient profiles. Composition Bonetta Deep Cross-Linked HA Filler Active Ingredients Cross-Linked Hyaluronic Acid 24 mg/mL Non-animal hyaluronic acid produced by bacterial fermentation, cross-linked using ExoCoBio Inc.’s HENM Patented Cross-Linking technology. The cross-linking process creates a stable, durable gel matrix that resists rapid enzymatic breakdown in tissue. Phosphate-buffered saline carries the gel at near-physiological pH. Lidocaine HCl 0.3% (3 mg/mL) Premixed local anaesthetic at the industry-standard 0.3% concentration. Reduces injection-site discomfort and eliminates the need for on-site mixing with separate lidocaine vials. The lidocaine itself wears off within hours of injection and does not affect long-term gel duration. Clinical Indications Where Bonetta Deep Cross-Linked HA Filler Is Used Nasolabial Folds Primary indication. Mid-to-deep dermal placement for moderate-to-severe nose-to-mouth lines. HENM cross-linking provides sustained correction. Lip Augmentation Lip body volumising and contour enhancement. The 2-syringe pack supports comprehensive lip work in one session. Cheek Volumising Mid-density cheek augmentation. Subcutaneous placement for restoring age-related midface volume loss. Marionette & Perioral Lines Moderate oral commissure-to-jaw furrows and deeper perioral folds. The 27G needle suits this anatomical zone. Side-By-Side Bonetta Deep Cross-Linked HA Filler vs Juvederm vs Restylane Feature Bonetta Juvederm (Allergan) Restylane (Galderma) HA Concentration 24 mg/mL 15–24 mg/mL 20 mg/mL Cross-Linking Tech HENM Vycross / Hylacross NASHA® / OBT Lidocaine 0.3% (premixed) 0.3% (XC lines) 0.3% (Lidocaine variants) Duration 9–18 months 6–24 months (varies) 6–18 months (varies) Origin South Korea (ExoCoBio Inc.) USA (Allergan / AbbVie) Sweden (Galderma) Established Since 2017 2006 1996 ↔ Swipe horizontally on mobile to view all columns Comparison based on manufacturer published data. See our top dermal filler comparison guide for broader market context. Specifications Bonetta Deep Cross-Linked HA Filler Product Specifications Manufacturer Brand: Bonetta Company: ExoCoBio Inc. Country: South Korea Established: 2017 Formula HA Source: Non-animal bacterial fermentation HA Concentration: 24 mg/mL Lidocaine: 0.3% (3 mg/mL) premixed Cross-linking: HENM Patented Cross-Linking Performance Duration: 9–18 months Injection Depth: Mid to deep dermis Recommended Needle: 27G Last Reviewed: May 2026 Approval & Storage Approvals: KFDA registered · GMP certified Packaging: 2 × 1.1 mL pre-filled syringes per box Storage: 2–25 °C, do not freeze Shelf life: 24 months unopened Verify regulatory status at the official Korean MFDS database — nedrug.mfds.go.kr. For market pricing context, see our dermal filler pricing guide. FAQs Bonetta Deep Cross-Linked HA Filler — Frequently Asked Questions What is Bonetta Deep Cross-Linked HA Filler? Bonetta Deep is ExoCoBio’s mid-density workhorse — 24 mg/mL cross-linked hyaluronic acid 0.3% lidocaine using patented HENM cross-linking technology. Supplied as 2 × 1.1 mL pre-filled syringes per box. Engineered for nasolabial folds, lip augmentation, and moderate facial contouring with 9–18 month durability. KFDA registered. Where is Bonetta Deep Cross-Linked HA Filler manufactured? Bonetta Deep Cross-Linked HA Filler is manufactured by ExoCoBio Inc., a South Korea-based medical device and pharmaceutical company established in 2017. The product is part of the Bonetta dermal filler range, which is distributed across multiple international markets. Regulatory status: KFDA registered · GMP certified. What is the HA concentration in Bonetta Deep Cross-Linked HA Filler? Bonetta Deep Cross-Linked HA Filler contains 24 mg/mL of cross-linked hyaluronic acid plus 0.3% (3 mg/mL) premixed lidocaine for injection comfort. The hyaluronic acid is non-animal, produced by bacterial fermentation and cross-linked using ExoCoBio Inc.’s HENM Patented Cross-Linking technology. Phosphate-buffered saline at near-physiological pH carries the gel. How long do Bonetta Deep Cross-Linked HA Filler results last? Per ExoCoBio Inc.’s clinical data, Bonetta Deep Cross-Linked HA Filler delivers 9–18 months of correction depending on placement and patient factors. Duration depends on injection depth, dose, anatomical site, patient metabolism, and facial movement intensity. Mid to deep dermis placement typically delivers the longer end of the duration range. What is the recommended injection depth for Bonetta Deep Cross-Linked HA Filler? Bonetta Deep Cross-Linked HA Filler is engineered for mid to deep dermis placement. The standard recommended needle is 27G, supplied in the syringe blister pack. Some practitioners prefer a blunt-tip cannula of equivalent gauge for safer placement in highly vascular zones, particularly for deeper subcutaneous work. Is Bonetta Deep Cross-Linked HA Filler FDA approved or CE marked? Bonetta Deep Cross-Linked HA Filler regulatory status: KFDA registered · GMP certified. The product’s KFDA registration in South Korea is the primary regulatory baseline. CE marking and other international approvals enable distribution in the EU and other regulated markets. US FDA status varies — buyers in regulated jurisdictions should verify approval scope before importation and clinical use. How should Bonetta Deep Cross-Linked HA Filler be stored at the clinic? Store Bonetta Deep Cross-Linked HA Filler between 2 °C and 25 °C in original packaging, away from direct sunlight. Do not freeze — freezing damages the HA gel structure. Shelf life is typically 24 months from the manufacturing date printed on the box when unopened. Once a syringe is opened, contents must be used immediately. Partial syringes cannot be retained for later use due to sterility risk. Does Bonetta Deep Cross-Linked HA Filler contain animal-derived ingredients? No. Bonetta Deep Cross-Linked HA Filler uses non-animal hyaluronic acid produced by bacterial fermentation — the standard manufacturing approach for modern HA dermal fillers. The product contains no animal proteins or by-products, making it suitable for patients who avoid animal-derived medical products. The product is contraindicated in patients with severe allergies to gram-positive bacterial proteins (used in HA fermentation). Can Bonetta Deep Cross-Linked HA Filler be combined with other dermal fillers in the same session? Yes — layered protocols combining different fillers are standard aesthetic practice. Bonetta Deep Cross-Linked HA Filler can be combined with other Korean or international HA fillers, neuromodulators (botulinum toxin), or biostimulators (PLLA, calcium hydroxylapatite) within a single session. Always wait the recommended interval between different injectable products and confirm biocompatibility per each manufacturer’s IFU. What is HENM cross-linking technology? HENM is ExoCoBio’s proprietary cross-linking process used across the Bonetta line. The technology produces a uniformly cross-linked HA gel structure with optimised viscoelasticity — allowing smooth extrusion through a fine needle while maintaining structural integrity post-injection. The result: even gel distribution, reduced risk of post-injection edema and bruising, and sustained shape retention over 9–18 months for the Deep variant. 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Browse category → Important Safety Information Read Before Clinical Use Bonetta Deep Cross-Linked HA Filler is a prescription medical device for use only by licensed aesthetic practitioners. Common reactions include injection-site bruising, swelling, redness, and tenderness — generally resolving within days. Like all hyaluronic acid dermal fillers, treatment carries rare but serious vascular complication risks. Contraindicated in patients with known hypersensitivity to hyaluronic acid or lidocaine, active skin infection at the treatment site, pregnancy, or breastfeeding. Full contraindications, vascular complication protocols, aftercare, and emergency guidance are detailed on the dermal filler safety page. Read Full Dermal Filler Safety Information → Bonetta is a registered trademark of ExoCoBio Inc.. Fillersfairy.com is a channel distributor and does not provide medical advice. This page is for informational purposes only and does not replace the manufacturer’s official Instructions for Use, which remains the authoritative source for clinical administration. Regulatory status varies by jurisdiction — buyers are responsible for verifying legal status before ordering. Last reviewed May 2026 against ExoCoBio Inc. manufacturer documentation.