Chaeum Series · Fine lines, periorbital wrinkles, lip contouring Chaeum Premium 1 — Monophasic HA Filler for Fine Wrinkles (1/4 Cross-Link Rate) Chaeum Premium 1 is Hugel Pharma’s lightest monophasic HA filler — 24 mg/mL cross-linked hyaluronic acid 0.3% lidocaine at the lowest cross-linking rate (1/4) in the Chaeum Premium series. Engineered for superficial-to-mid dermis placement. Endotoxin under 0.03 EU/mL, BDDE residual under 0.5 ppm. Supplied as 2 × 1.1 mL syringes per box. Professional use only — for licensed aesthetic practitioners. Manufacturer: Hugel Pharma Co. Ltd., South Korea · Established 2001 1/4 Cross-Link Rate 2 × 1.1mL Per Box May 2026 Last Reviewed · Verified Hugel Pharma Co. Ltd. Technology How Chaeum Premium 1 Hyaluronic Acid Filler Is Engineered 1 Monophasic Cross-Linking (1/4 Rate) Hugel Pharma Co. Ltd.’s proprietary cross-linking process produces a stabilised HA gel matrix engineered for sustained tissue retention. The technology balances viscoelasticity (firmness for projection) with extrusion smoothness (easier injection through the 30G needle). The result: predictable handling, consistent gel distribution, and 6–9 months durability in superficial to mid dermis placement. 2 Quality & Purity Non-animal hyaluronic acid produced by bacterial fermentation. Endotoxin levels controlled below international safety thresholds. Stringent manufacturing under GMP-certified conditions minimises BDDE residue, heavy metals, and protein contaminants — reducing the risk of post-injection inflammation, granuloma formation, or hypersensitivity reactions in suitable patient profiles. Composition Chaeum Premium 1 Hyaluronic Acid Filler Active Ingredients Cross-Linked Hyaluronic Acid 24 mg/mL Non-animal hyaluronic acid produced by bacterial fermentation, cross-linked using Hugel Pharma Co. Ltd.’s Monophasic Cross-Linking (1/4 Rate) technology. The cross-linking process creates a stable, durable gel matrix that resists rapid enzymatic breakdown in tissue. Phosphate-buffered saline carries the gel at near-physiological pH. Lidocaine HCl 0.3% (3 mg/mL) Premixed local anaesthetic at the industry-standard 0.3% concentration. Reduces injection-site discomfort and eliminates the need for on-site mixing with separate lidocaine vials. The lidocaine itself wears off within hours of injection and does not affect long-term gel duration. Clinical Indications Where Chaeum Premium 1 Hyaluronic Acid Filler Is Used Glabella & Forehead Lines Fine vertical and horizontal forehead wrinkles. Superficial dermal placement using the 30G needle. Periorbital Crow’s Feet Fine lines around the eyes. The 1/4 cross-link rate produces a soft gel suitable for thin periorbital skin. Perioral Smoker’s Lines Fine perioral wrinkles. The low-viscosity gel reduces lump risk in this delicate area. Lip Contouring Subtle lip border definition and mild hydration. Not for dramatic volumising. Side-By-Side Chaeum Premium 1 Hyaluronic Acid Filler vs Juvederm vs Restylane Feature Chaeum Juvederm (Allergan) Restylane (Galderma) HA Concentration 24 mg/mL 15–24 mg/mL 20 mg/mL Cross-Linking Tech Monophasic Vycross / Hylacross NASHA® / OBT Lidocaine 0.3% (premixed) 0.3% (XC lines) 0.3% (Lidocaine variants) Duration 6–9 months 6–24 months (varies) 6–18 months (varies) Origin South Korea (Hugel Pharma Co. Ltd.) USA (Allergan / AbbVie) Sweden (Galderma) Established Since 2001 2006 1996 ↔ Swipe horizontally on mobile to view all columns Comparison based on manufacturer published data. See our top dermal filler comparison guide for broader market context. Specifications Chaeum Premium 1 Hyaluronic Acid Filler Product Specifications Manufacturer Brand: Chaeum Company: Hugel Pharma Co. Ltd. Country: South Korea Established: 2001 Formula HA Source: Non-animal bacterial fermentation HA Concentration: 24 mg/mL Lidocaine: 0.3% (3 mg/mL) premixed Cross-linking: Monophasic Cross-Linking (1/4 Rate) Performance Duration: 6–9 months Injection Depth: Superficial to mid dermis Recommended Needle: 30G Last Reviewed: May 2026 Approval & Storage Approvals: KFDA registered (3-2021-8521) · GMP certified Packaging: 2 × 1.1 mL pre-filled syringes 4 × 30G needles Storage: 2–25 °C, do not freeze Shelf life: 24 months unopened Verify regulatory status at the official Korean MFDS database — nedrug.mfds.go.kr. For market pricing context, see our dermal filler pricing guide. FAQs Chaeum Premium 1 Hyaluronic Acid Filler — Frequently Asked Questions What is Chaeum Premium 1 Hyaluronic Acid Filler? Chaeum Premium 1 is Hugel Pharma’s lightest monophasic HA filler — 24 mg/mL cross-linked hyaluronic acid 0.3% lidocaine at the lowest cross-linking rate (1/4) in the Chaeum Premium series. Engineered for superficial-to-mid dermis placement. Endotoxin under 0.03 EU/mL, BDDE residual under 0.5 ppm. Supplied as 2 × 1.1 mL syringes per box. Where is Chaeum Premium 1 Hyaluronic Acid Filler manufactured? Chaeum Premium 1 Hyaluronic Acid Filler is manufactured by Hugel Pharma Co. Ltd., a South Korea-based medical device and pharmaceutical company established in 2001. The product is part of the Chaeum dermal filler range, which is distributed across multiple international markets. Regulatory status: KFDA registered (3-2021-8521) · GMP certified. What is the HA concentration in Chaeum Premium 1 Hyaluronic Acid Filler? Chaeum Premium 1 Hyaluronic Acid Filler contains 24 mg/mL of cross-linked hyaluronic acid plus 0.3% (3 mg/mL) premixed lidocaine for injection comfort. The hyaluronic acid is non-animal, produced by bacterial fermentation and cross-linked using Hugel Pharma Co. Ltd.’s Monophasic Cross-Linking (1/4 Rate) technology. Phosphate-buffered saline at near-physiological pH carries the gel. How long do Chaeum Premium 1 Hyaluronic Acid Filler results last? Per Hugel Pharma Co. Ltd.’s clinical data, Chaeum Premium 1 Hyaluronic Acid Filler delivers 6–9 months of correction depending on placement and patient factors. Duration depends on injection depth, dose, anatomical site, patient metabolism, and facial movement intensity. Superficial to mid dermis placement typically delivers the longer end of the duration range. What is the recommended injection depth for Chaeum Premium 1 Hyaluronic Acid Filler? Chaeum Premium 1 Hyaluronic Acid Filler is engineered for superficial to mid dermis placement. The standard recommended needle is 30G, supplied in the syringe blister pack. Some practitioners prefer a blunt-tip cannula of equivalent gauge for safer placement in highly vascular zones, particularly for deeper subcutaneous work. Is Chaeum Premium 1 Hyaluronic Acid Filler FDA approved or CE marked? Chaeum Premium 1 Hyaluronic Acid Filler regulatory status: KFDA registered (3-2021-8521) · GMP certified. The product’s KFDA registration in South Korea is the primary regulatory baseline. CE marking and other international approvals enable distribution in the EU and other regulated markets. US FDA status varies — buyers in regulated jurisdictions should verify approval scope before importation and clinical use. How should Chaeum Premium 1 Hyaluronic Acid Filler be stored at the clinic? Store Chaeum Premium 1 Hyaluronic Acid Filler between 2 °C and 25 °C in original packaging, away from direct sunlight. Do not freeze — freezing damages the HA gel structure. Shelf life is typically 24 months from the manufacturing date printed on the box when unopened. Once a syringe is opened, contents must be used immediately. Partial syringes cannot be retained for later use due to sterility risk. Does Chaeum Premium 1 Hyaluronic Acid Filler contain animal-derived ingredients? No. Chaeum Premium 1 Hyaluronic Acid Filler uses non-animal hyaluronic acid produced by bacterial fermentation — the standard manufacturing approach for modern HA dermal fillers. The product contains no animal proteins or by-products, making it suitable for patients who avoid animal-derived medical products. The product is contraindicated in patients with severe allergies to gram-positive bacterial proteins (used in HA fermentation). Can Chaeum Premium 1 Hyaluronic Acid Filler be combined with other dermal fillers in the same session? Yes — layered protocols combining different fillers are standard aesthetic practice. Chaeum Premium 1 Hyaluronic Acid Filler can be combined with other Korean or international HA fillers, neuromodulators (botulinum toxin), or biostimulators (PLLA, calcium hydroxylapatite) within a single session. Always wait the recommended interval between different injectable products and confirm biocompatibility per each manufacturer’s IFU. What does ‘1/4 cross-link rate’ mean in Chaeum Premium 1? Hugel Pharma rates the Chaeum Premium series on a 1-to-4 cross-linking scale, where Premium 1 has the lowest cross-link density and Premium 4 has the highest. Lower cross-linking produces a softer, more pliable gel suitable for superficial dermal placement (fine lines, delicate zones). Higher cross-linking produces a firmer gel for deep tissue placement (cheek augmentation, jawline contouring). All four Chaeum Premium variants share the same HA source and 0.3% lidocaine concentration — the cross-link rate is the variant differentiator. 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Browse category → Important Safety Information Read Before Clinical Use Chaeum Premium 1 Hyaluronic Acid Filler is a prescription medical device for use only by licensed aesthetic practitioners. Common reactions include injection-site bruising, swelling, redness, and tenderness — generally resolving within days. Like all hyaluronic acid dermal fillers, treatment carries rare but serious vascular complication risks. Contraindicated in patients with known hypersensitivity to hyaluronic acid or lidocaine, active skin infection at the treatment site, pregnancy, or breastfeeding. Full contraindications, vascular complication protocols, aftercare, and emergency guidance are detailed on the dermal filler safety page. Read Full Dermal Filler Safety Information → Chaeum is a registered trademark of Hugel Pharma Co. Ltd.. Fillersfairy.com is a channel distributor and does not provide medical advice. This page is for informational purposes only and does not replace the manufacturer’s official Instructions for Use, which remains the authoritative source for clinical administration. Regulatory status varies by jurisdiction — buyers are responsible for verifying legal status before ordering. Last reviewed May 2026 against Hugel Pharma Co. Ltd. manufacturer documentation.