Celosome Series · Deep wrinkles, cheek augmentation, jawline contouring Celosome Strong — High-Density HENM Filler for Deep Wrinkles & Facial Contouring Celosome Strong is ExCoBio’s high-density variant — 24 mg/mL cross-linked HA 0.3% lidocaine with the most pronounced HENM cross-linking in the standard Celosome range. Engineered for deep dermis and subcutaneous placement with 12–24 month durability. Targets deep wrinkles, cheek augmentation, jawline definition. KFDA registered. Professional use only — for licensed aesthetic practitioners. Manufacturer: ExCoBio Co. Ltd., South Korea · Established 2017 HENM High Density 8-Phase Purification May 2026 Last Reviewed · Verified ExCoBio Co. Ltd. Technology How Celosome Strong Hyaluronic Acid Filler Is Engineered 1 HENM 8-Phase Purification (High Density) ExCoBio Co. Ltd.’s proprietary cross-linking process produces a stabilised HA gel matrix engineered for sustained tissue retention. The technology balances viscoelasticity (firmness for projection) with extrusion smoothness (easier injection through the 27G needle). The result: predictable handling, consistent gel distribution, and 12–24 months durability in deep dermis placement. 2 Quality & Purity Non-animal hyaluronic acid produced by bacterial fermentation. Endotoxin levels controlled below international safety thresholds. Stringent manufacturing under GMP-certified conditions minimises BDDE residue, heavy metals, and protein contaminants — reducing the risk of post-injection inflammation, granuloma formation, or hypersensitivity reactions in suitable patient profiles. Composition Celosome Strong Hyaluronic Acid Filler Active Ingredients Cross-Linked Hyaluronic Acid 24 mg/mL Non-animal hyaluronic acid produced by bacterial fermentation, cross-linked using ExCoBio Co. Ltd.’s HENM 8-Phase Purification (High Density) technology. The cross-linking process creates a stable, durable gel matrix that resists rapid enzymatic breakdown in tissue. Phosphate-buffered saline carries the gel at near-physiological pH. Lidocaine HCl 0.3% (3 mg/mL) Premixed local anaesthetic at the industry-standard 0.3% concentration. Reduces injection-site discomfort and eliminates the need for on-site mixing with separate lidocaine vials. The lidocaine itself wears off within hours of injection and does not affect long-term gel duration. Clinical Indications Where Celosome Strong Hyaluronic Acid Filler Is Used Deep Nasolabial Folds Pronounced nose-to-mouth folds requiring structural fill. High cross-linking density maintains correction over 12–24 months. Cheek & Midface Volume Deep subcutaneous placement for sustained cheekbone projection and midface lift. Jawline Contouring Non-surgical jawline definition. The high firmness supports angular projection without dissipation. Facial Sculpting Multi-zone contouring including chin and lateral face. Celosome Strong’s durability suits patients seeking sustained results. Side-By-Side Celosome Strong Hyaluronic Acid Filler vs Juvederm vs Restylane Feature Celosome Juvederm (Allergan) Restylane (Galderma) HA Concentration 24 mg/mL 15–24 mg/mL 20 mg/mL Cross-Linking Tech HENM Vycross / Hylacross NASHA® / OBT Lidocaine 0.3% (premixed) 0.3% (XC lines) 0.3% (Lidocaine variants) Duration 12–24 months 6–24 months (varies) 6–18 months (varies) Origin South Korea (ExCoBio Co. Ltd.) USA (Allergan / AbbVie) Sweden (Galderma) Established Since 2017 2006 1996 ↔ Swipe horizontally on mobile to view all columns Comparison based on manufacturer published data. See our top dermal filler comparison guide for broader market context. Specifications Celosome Strong Hyaluronic Acid Filler Product Specifications Manufacturer Brand: Celosome Company: ExCoBio Co. Ltd. Country: South Korea Established: 2017 Formula HA Source: Non-animal bacterial fermentation HA Concentration: 24 mg/mL Lidocaine: 0.3% (3 mg/mL) premixed Cross-linking: HENM 8-Phase Purification (High Density) Performance Duration: 12–24 months Injection Depth: Deep dermis · subcutaneous Recommended Needle: 27G Last Reviewed: May 2026 Approval & Storage Approvals: KFDA registered · GMP certified Packaging: 1 × 1.1 mL pre-filled syringe Storage: 2–25 °C, do not freeze Shelf life: 24 months unopened Verify regulatory status at the official Korean MFDS database — nedrug.mfds.go.kr. For market pricing context, see our dermal filler pricing guide. FAQs Celosome Strong Hyaluronic Acid Filler — Frequently Asked Questions What is Celosome Strong Hyaluronic Acid Filler? Celosome Strong is ExCoBio’s high-density variant — 24 mg/mL cross-linked HA 0.3% lidocaine with the most pronounced HENM cross-linking in the standard Celosome range. Engineered for deep dermis and subcutaneous placement with 12–24 month durability. Targets deep wrinkles, cheek augmentation, jawline definition. KFDA registered. Where is Celosome Strong Hyaluronic Acid Filler manufactured? Celosome Strong Hyaluronic Acid Filler is manufactured by ExCoBio Co. Ltd., a South Korea-based medical device and pharmaceutical company established in 2017. The product is part of the Celosome dermal filler range, which is distributed across multiple international markets. Regulatory status: KFDA registered · GMP certified. What is the HA concentration in Celosome Strong Hyaluronic Acid Filler? Celosome Strong Hyaluronic Acid Filler contains 24 mg/mL of cross-linked hyaluronic acid plus 0.3% (3 mg/mL) premixed lidocaine for injection comfort. The hyaluronic acid is non-animal, produced by bacterial fermentation and cross-linked using ExCoBio Co. Ltd.’s HENM 8-Phase Purification (High Density) technology. Phosphate-buffered saline at near-physiological pH carries the gel. How long do Celosome Strong Hyaluronic Acid Filler results last? Per ExCoBio Co. Ltd.’s clinical data, Celosome Strong Hyaluronic Acid Filler delivers 12–24 months of correction depending on placement and patient factors. Duration depends on injection depth, dose, anatomical site, patient metabolism, and facial movement intensity. Deep dermis placement typically delivers the longer end of the duration range. What is the recommended injection depth for Celosome Strong Hyaluronic Acid Filler? Celosome Strong Hyaluronic Acid Filler is engineered for deep dermis · subcutaneous placement. The standard recommended needle is 27G, supplied in the syringe blister pack. Some practitioners prefer a blunt-tip cannula of equivalent gauge for safer placement in highly vascular zones, particularly for deeper subcutaneous work. Is Celosome Strong Hyaluronic Acid Filler FDA approved or CE marked? Celosome Strong Hyaluronic Acid Filler regulatory status: KFDA registered · GMP certified. The product’s KFDA registration in South Korea is the primary regulatory baseline. CE marking and other international approvals enable distribution in the EU and other regulated markets. US FDA status varies — buyers in regulated jurisdictions should verify approval scope before importation and clinical use. How should Celosome Strong Hyaluronic Acid Filler be stored at the clinic? Store Celosome Strong Hyaluronic Acid Filler between 2 °C and 25 °C in original packaging, away from direct sunlight. Do not freeze — freezing damages the HA gel structure. Shelf life is typically 24 months from the manufacturing date printed on the box when unopened. Once a syringe is opened, contents must be used immediately. Partial syringes cannot be retained for later use due to sterility risk. Does Celosome Strong Hyaluronic Acid Filler contain animal-derived ingredients? No. Celosome Strong Hyaluronic Acid Filler uses non-animal hyaluronic acid produced by bacterial fermentation — the standard manufacturing approach for modern HA dermal fillers. The product contains no animal proteins or by-products, making it suitable for patients who avoid animal-derived medical products. The product is contraindicated in patients with severe allergies to gram-positive bacterial proteins (used in HA fermentation). Can Celosome Strong Hyaluronic Acid Filler be combined with other dermal fillers in the same session? Yes — layered protocols combining different fillers are standard aesthetic practice. Celosome Strong Hyaluronic Acid Filler can be combined with other Korean or international HA fillers, neuromodulators (botulinum toxin), or biostimulators (PLLA, calcium hydroxylapatite) within a single session. Always wait the recommended interval between different injectable products and confirm biocompatibility per each manufacturer’s IFU. How does Celosome Strong compare to Celosome Implant? Both are high-density variants but differ in viscoelasticity. Celosome Strong (12–24 month durability) suits deep dermis to subcutaneous placement for cheek, jawline, and deep folds. Celosome Implant (12–24 month durability) is engineered specifically for deep subcutaneous to supraperiosteal layers for the most structural projection — typically chin augmentation, severe contouring, and significant facial sculpting. Practitioners select Strong for deep-dermal-to-subcutaneous correction and Implant for the deepest, most structural placements. 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Browse category → Important Safety Information Read Before Clinical Use Celosome Strong Hyaluronic Acid Filler is a prescription medical device for use only by licensed aesthetic practitioners. Common reactions include injection-site bruising, swelling, redness, and tenderness — generally resolving within days. Deep placement (subcutaneous and supraperiosteal layers) involves heightened anatomical awareness of facial vasculature; practitioners require access to hyaluronidase for emergency dissolution. Like all hyaluronic acid dermal fillers, treatment carries rare but serious vascular complication risks. Contraindicated in patients with known hypersensitivity to hyaluronic acid or lidocaine, active skin infection at the treatment site, pregnancy, or breastfeeding. Full contraindications, vascular complication protocols, aftercare, and emergency guidance are detailed on the dermal filler safety page. Read Full Dermal Filler Safety Information → Celosome is a registered trademark of ExCoBio Co. Ltd.. Fillersfairy.com is a channel distributor and does not provide medical advice. This page is for informational purposes only and does not replace the manufacturer’s official Instructions for Use, which remains the authoritative source for clinical administration. Regulatory status varies by jurisdiction — buyers are responsible for verifying legal status before ordering. Last reviewed May 2026 against ExCoBio Co. Ltd. manufacturer documentation.