Neo Pro Cream 450G Liposomal 10.56% Lidocaine – Fast Onset, Clean Wipe-Off, Large-Capacity Jar Neo Pro Cream 450G is a medical-grade 10.56% lidocaine emulsion (45.5g active lidocaine per jar) engineered for clinical dermatological and aesthetic procedures. Its liposomal delivery system is built into a water-in-oil (W/O) emulsion at pH 6.5–7.0, giving a rapid 15–20 minute onset and sustained anesthesia for 90–120 minutes post-removal. The 450g jar makes it practical for high-frequency clinical use across laser therapies, microneedling, and extensive pigmentation or tattoo sessions. Indicated Procedures Microneedling A 20-minute occlusion is reported by clinicians to achieve excellent anesthetic depth before microneedling. Picosecond & Other Lasers Used ahead of picosecond laser sessions and laser hair removal for high-frequency clinic days. Mesotherapy Pre-treatment numbing for mesotherapy injection points. Large-Area Tattoo Work Thicker consistency holds in place for larger tattoo pieces requiring extended numbing coverage. Clinical Specifications Active Ingredient10.56% Lidocaine (45.5g active per 450g jar) Delivery SystemLiposomal encapsulation in a water-in-oil (W/O) emulsion Density1.5g/cm³ pH Level6.5 – 7.0 (skin barrier compatible) Onset Time15 – 20 minutes (liposomal) Duration90 – 120 minutes post-removal Storage2°C – 25°C, avoid UV exposure Shelf Life24 months unopened / 6 months after opening Format450g sterile clinical jar How to Use Degrease & sanitize: Clean the target epidermis with 70% isopropyl alcohol and ensure the area is completely dry. Apply: Dispense approximately 0.5g per cm² in a uniform 1.5–2.0mm opaque layer over the treatment area. Occlude: Cover with a non-breathable plastic film to prevent evaporation and accelerate thermal absorption. Maintain for 15–25 minutes. Remove film: Take off the film once the occlusion window is complete. Wipe residue: Extract all residual emulsion with sterile gauze. Do not begin laser or needle work while surface residue is present. Frequently Asked Questions How does Neo Pro’s liposomal formula compare to older 10.56% lidocaine creams that leave a greasy residue? Clinics that previously used older single-emulsion 10.56% lidocaine formulas often report a slippery residue that remains even after wiping, which can interfere with a practitioner’s grip during injections. Neo Pro’s liposomal delivery system encapsulates the lidocaine in lipid-based carriers within a water-in-oil emulsion, which is reported to wipe off cleanly and dry once the occlusion film is removed and the area is gauzed, while maintaining the same 10.56% medical-grade numbing strength. This makes the post-removal handling noticeably different from older greasier formulations, without changing the active ingredient concentration. Why is the occlusion window only 15–25 minutes, when some other numbing creams call for 30–60 minutes? Neo Pro’s liposomal encapsulation is specifically designed to accelerate absorption – the lipid carriers help the active lidocaine cross the stratum corneum faster than it would in a standard emulsion. This is why the rated onset is 15–20 minutes rather than 30 minutes seen on slower-penetrating formulas. The 15–25 minute occlusion protocol is matched to this faster absorption profile. Leaving the product on significantly longer than this window – for example over an hour – is not recommended, as prolonged occlusion can cause excessive blanching of the skin. What does the “1.5g/cm³ density” specification mean, and why does it matter for dosing? Density tells you how much the cream weighs for a given volume – 1.5 grams per cubic centimeter. Combined with the application guidance of approximately 0.5g per cm² in a 1.5–2.0mm layer, this lets practitioners estimate how much product is needed for a given treatment area and how many applications a 450g jar will support. A higher-density emulsion like this also tends to sit on the skin without running, which is part of why reviewers describe the consistency as “thick” and suitable for larger areas such as tattoo work. The label caps cumulative application area at 400cm² (20cm x 20cm) per 24 hours – what does that mean for a large tattoo session? The 400cm² limit (roughly an 8×8 inch square) refers to the total skin surface area that should receive this product within any 24-hour period, to keep systemic lidocaine absorption within safe limits. For a tattoo piece larger than 400cm², this means the numbing cream should be applied and worked in sections rather than to the entire piece at once in a single session, with the total area treated in one day kept within this ceiling. This is a systemic-safety limit related to how much lidocaine the body absorbs, not a limit on how much product is in the jar. The product description says transient erythema and blanching are “normal” – how do I tell normal redness/blanching from a reaction I should stop for? Transient erythema (mild, temporary redness) and blanching (a pale, whitened appearance) are common, expected responses to topical anesthetics and occlusion – they typically fade within a short time after the product is removed and do not come with pain, swelling, or texture changes. Signs that go beyond this normal range – such as raised welts, blistering, persistent swelling, intense itching, or skin that stays significantly discolored well after removal – are not part of the expected response and application should be stopped and the area assessed if these occur. ⚠ Safety Information & Contraindications Contraindications Documented amide-type local anesthetic hypersensitivity Severe hepatic impairment Mucous membrane contact Stop Use If You Notice Blistering, welts, or skin breakdown Redness or blanching that persists well beyond removal Signs of systemic toxicity (dizziness, ringing in ears, irregular heartbeat) Authorized for professional administration by licensed aesthetic and medical practitioners only. Maximum cumulative application area must not exceed 400cm² (approx. 20cm x 20cm) within a 24-hour period. This product is not a substitute for medical advice.