Celosome Series · Mid-to-deep wrinkles, cheek augmentation, liquid facelift Celosome Mid — Medium-Density HENM Filler for Mid-to-Deep Wrinkles & Liquid Facelift Celosome Mid is ExCoBio’s medium-density variant — 24 mg/mL cross-linked HA 0.3% lidocaine with HENM cross-linking and 8-phase purification. Engineered for mid-to-deep dermal placement: nasolabial folds, cheek augmentation, and liquid facelift protocols. 9–18 month durability. KFDA registered. Professional use only — for licensed aesthetic practitioners. Manufacturer: ExCoBio Co. Ltd., South Korea · Established 2017 HENM Medium Density 8-Phase Purification May 2026 Last Reviewed · Verified ExCoBio Co. Ltd. Technology How Celosome Mid Hyaluronic Acid Filler Is Engineered 1 HENM 8-Phase Purification ExCoBio Co. Ltd.’s proprietary cross-linking process produces a stabilised HA gel matrix engineered for sustained tissue retention. The technology balances viscoelasticity (firmness for projection) with extrusion smoothness (easier injection through the 27G needle). The result: predictable handling, consistent gel distribution, and 9–18 months durability in mid to deep dermis placement. 2 Quality & Purity Non-animal hyaluronic acid produced by bacterial fermentation. Endotoxin levels controlled below international safety thresholds. Stringent manufacturing under GMP-certified conditions minimises BDDE residue, heavy metals, and protein contaminants — reducing the risk of post-injection inflammation, granuloma formation, or hypersensitivity reactions in suitable patient profiles. Composition Celosome Mid Hyaluronic Acid Filler Active Ingredients Cross-Linked Hyaluronic Acid 24 mg/mL Non-animal hyaluronic acid produced by bacterial fermentation, cross-linked using ExCoBio Co. Ltd.’s HENM 8-Phase Purification technology. The cross-linking process creates a stable, durable gel matrix that resists rapid enzymatic breakdown in tissue. Phosphate-buffered saline carries the gel at near-physiological pH. Lidocaine HCl 0.3% (3 mg/mL) Premixed local anaesthetic at the industry-standard 0.3% concentration. Reduces injection-site discomfort and eliminates the need for on-site mixing with separate lidocaine vials. The lidocaine itself wears off within hours of injection and does not affect long-term gel duration. Clinical Indications Where Celosome Mid Hyaluronic Acid Filler Is Used Nasolabial Folds Primary indication. Mid-to-deep dermal placement for moderate nose-to-mouth lines. Sustained 9–18 month correction. Cheek Augmentation Midface volumising and cheekbone enhancement. The medium cross-linking density provides sustained projection without rigidity. Liquid Facelift Multi-point injection protocol for non-surgical facial lift. Celosome Mid is the workhorse variant for these protocols. Lip Contouring Lip body volumising and vermillion border definition. The 27G needle suits lip body placement. Side-By-Side Celosome Mid Hyaluronic Acid Filler vs Juvederm vs Restylane Feature Celosome Juvederm (Allergan) Restylane (Galderma) HA Concentration 24 mg/mL 15–24 mg/mL 20 mg/mL Cross-Linking Tech HENM Vycross / Hylacross NASHA® / OBT Lidocaine 0.3% (premixed) 0.3% (XC lines) 0.3% (Lidocaine variants) Duration 9–18 months 6–24 months (varies) 6–18 months (varies) Origin South Korea (ExCoBio Co. Ltd.) USA (Allergan / AbbVie) Sweden (Galderma) Established Since 2017 2006 1996 ↔ Swipe horizontally on mobile to view all columns Comparison based on manufacturer published data. See our top dermal filler comparison guide for broader market context. Specifications Celosome Mid Hyaluronic Acid Filler Product Specifications Manufacturer Brand: Celosome Company: ExCoBio Co. Ltd. Country: South Korea Established: 2017 Formula HA Source: Non-animal bacterial fermentation HA Concentration: 24 mg/mL Lidocaine: 0.3% (3 mg/mL) premixed Cross-linking: HENM 8-Phase Purification Performance Duration: 9–18 months Injection Depth: Mid to deep dermis Recommended Needle: 27G Last Reviewed: May 2026 Approval & Storage Approvals: KFDA registered · GMP certified Packaging: 1 × 1.1 mL pre-filled syringe Storage: 2–25 °C, do not freeze Shelf life: 24 months unopened Verify regulatory status at the official Korean MFDS database — nedrug.mfds.go.kr. For market pricing context, see our dermal filler pricing guide. FAQs Celosome Mid Hyaluronic Acid Filler — Frequently Asked Questions What is Celosome Mid Hyaluronic Acid Filler? Celosome Mid is ExCoBio’s medium-density variant — 24 mg/mL cross-linked HA 0.3% lidocaine with HENM cross-linking and 8-phase purification. Engineered for mid-to-deep dermal placement: nasolabial folds, cheek augmentation, and liquid facelift protocols. 9–18 month durability. KFDA registered. Where is Celosome Mid Hyaluronic Acid Filler manufactured? Celosome Mid Hyaluronic Acid Filler is manufactured by ExCoBio Co. Ltd., a South Korea-based medical device and pharmaceutical company established in 2017. The product is part of the Celosome dermal filler range, which is distributed across multiple international markets. Regulatory status: KFDA registered · GMP certified. What is the HA concentration in Celosome Mid Hyaluronic Acid Filler? Celosome Mid Hyaluronic Acid Filler contains 24 mg/mL of cross-linked hyaluronic acid plus 0.3% (3 mg/mL) premixed lidocaine for injection comfort. The hyaluronic acid is non-animal, produced by bacterial fermentation and cross-linked using ExCoBio Co. Ltd.’s HENM 8-Phase Purification technology. Phosphate-buffered saline at near-physiological pH carries the gel. How long do Celosome Mid Hyaluronic Acid Filler results last? Per ExCoBio Co. Ltd.’s clinical data, Celosome Mid Hyaluronic Acid Filler delivers 9–18 months of correction depending on placement and patient factors. Duration depends on injection depth, dose, anatomical site, patient metabolism, and facial movement intensity. Mid to deep dermis placement typically delivers the longer end of the duration range. What is the recommended injection depth for Celosome Mid Hyaluronic Acid Filler? Celosome Mid Hyaluronic Acid Filler is engineered for mid to deep dermis placement. The standard recommended needle is 27G, supplied in the syringe blister pack. Some practitioners prefer a blunt-tip cannula of equivalent gauge for safer placement in highly vascular zones, particularly for deeper subcutaneous work. Is Celosome Mid Hyaluronic Acid Filler FDA approved or CE marked? Celosome Mid Hyaluronic Acid Filler regulatory status: KFDA registered · GMP certified. The product’s KFDA registration in South Korea is the primary regulatory baseline. CE marking and other international approvals enable distribution in the EU and other regulated markets. US FDA status varies — buyers in regulated jurisdictions should verify approval scope before importation and clinical use. How should Celosome Mid Hyaluronic Acid Filler be stored at the clinic? Store Celosome Mid Hyaluronic Acid Filler between 2 °C and 25 °C in original packaging, away from direct sunlight. Do not freeze — freezing damages the HA gel structure. Shelf life is typically 24 months from the manufacturing date printed on the box when unopened. Once a syringe is opened, contents must be used immediately. Partial syringes cannot be retained for later use due to sterility risk. Does Celosome Mid Hyaluronic Acid Filler contain animal-derived ingredients? No. Celosome Mid Hyaluronic Acid Filler uses non-animal hyaluronic acid produced by bacterial fermentation — the standard manufacturing approach for modern HA dermal fillers. The product contains no animal proteins or by-products, making it suitable for patients who avoid animal-derived medical products. The product is contraindicated in patients with severe allergies to gram-positive bacterial proteins (used in HA fermentation). Can Celosome Mid Hyaluronic Acid Filler be combined with other dermal fillers in the same session? Yes — layered protocols combining different fillers are standard aesthetic practice. Celosome Mid Hyaluronic Acid Filler can be combined with other Korean or international HA fillers, neuromodulators (botulinum toxin), or biostimulators (PLLA, calcium hydroxylapatite) within a single session. Always wait the recommended interval between different injectable products and confirm biocompatibility per each manufacturer’s IFU. Which Celosome variant is most versatile? Celosome Mid is the most versatile variant in the ExCoBio Celosome range — its medium cross-linking density supports the widest range of indications, from nasolabial folds and cheek augmentation to liquid facelift protocols and lip contouring. When practitioners are unsure between Soft (too light) and Strong (too firm) for a given indication, Mid is often the default starting point with sustained 9–18 month durability. 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Browse category → Important Safety Information Read Before Clinical Use Celosome Mid Hyaluronic Acid Filler is a prescription medical device for use only by licensed aesthetic practitioners. Common reactions include injection-site bruising, swelling, redness, and tenderness — generally resolving within days. Like all hyaluronic acid dermal fillers, treatment carries rare but serious vascular complication risks. Contraindicated in patients with known hypersensitivity to hyaluronic acid or lidocaine, active skin infection at the treatment site, pregnancy, or breastfeeding. Full contraindications, vascular complication protocols, aftercare, and emergency guidance are detailed on the dermal filler safety page. Read Full Dermal Filler Safety Information → Celosome is a registered trademark of ExCoBio Co. Ltd.. Fillersfairy.com is a channel distributor and does not provide medical advice. This page is for informational purposes only and does not replace the manufacturer’s official Instructions for Use, which remains the authoritative source for clinical administration. Regulatory status varies by jurisdiction — buyers are responsible for verifying legal status before ordering. Last reviewed May 2026 against ExCoBio Co. Ltd. manufacturer documentation.